Human Granulocyte Collagenase

Human Granulocyte Collagenase

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete p...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1968-03, Vol.159 (3822), p.1483-1485
Hauptverfasser: Lazarus, Gerald S., Brown, Robert S., Daniels, John R., Fullmer, Harold M.
Format: Artikel
Sprache:eng
Schlagworte:
Chlorides
Collagens
Enzymes
Erythrocytes
Gels
Granulocytes
Leukocytes
Lymphocytes
Solar fibrils
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Beschreibung
Zusammenfassung:A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.159.3822.1483