Transformation of Human Lymphocytes: Inhibition by Homologous Alpha Globulin

An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulati...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1968-03, Vol.159 (3820), p.1243-1244
Hauptverfasser:	Cooperband, Sidney R., Bondevik, Helge, Schmid, Karl, Mannick, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha globulins Alpha-Globulins - pharmacology Antibodies Blood plasma Blood Proteins - biosynthesis Cell culture techniques Cell Differentiation Culture Techniques Cultured cells Depression, Chemical Diphtheria Toxoid - pharmacology DNA DNA - biosynthesis Gene expression regulation Humans Lectins - antagonists & inhibitors Lymphocytes Lymphocytes - immunology Phosphorus Isotopes Phytohemagglutinins Serum Albumin, Bovine - antagonists & inhibitors Tetanus Toxoid - pharmacology Tuberculin
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Zusammenfassung:	An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.159.3820.1243