N-Amidino-3-Amino-6-Chloropyrazinecarboxamide: A New Diuretic Which Antagonizes the Renal Actions of Aldosterone

N-Amidino-3-Amino-6-Chloropyrazinecarboxamide: A New Diuretic Which Antagonizes the Renal Actions of Aldosterone

Summary N-amidino-3-amino-6-chloropy-razinecarboxamide (ACP) was found to: 1) antagonize the renal actions of exogenously administered aldosterone, DCA and hydrocortisone in the adrenalectomized rat, 2) reverse the action of endogenously produced aldosterone in the intact rat, and 3) produce a marke...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-11, Vol.120 (2), p.364-367
Hauptverfasser: Glitzer, M. S., Steelman, S. L.
Format: Artikel
Sprache:eng
Schlagworte:
Aldosterone - pharmacology
Animals
Desoxycorticosterone - pharmacology
Diuretics - pharmacology
Hydrocortisone - pharmacology
Kidney - drug effects
Natriuresis
Potassium
Rats
Spironolactone - pharmacology
Triamterene - pharmacology
Urine
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Zusammenfassung:Summary N-amidino-3-amino-6-chloropy-razinecarboxamide (ACP) was found to: 1) antagonize the renal actions of exogenously administered aldosterone, DCA and hydrocortisone in the adrenalectomized rat, 2) reverse the action of endogenously produced aldosterone in the intact rat, and 3) produce a marked natriuresis and anti-kaluresis in the non-DCA treated rat. ACP was found to be 12.5 times as potent as spironolactone.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-120-30538