Protection by Orotic Acid Against the Renal Necrosis and Fatty Liver of Choline Deficiency

Protection by Orotic Acid Against the Renal Necrosis and Fatty Liver of Choline Deficiency

Summary Addition of 1% orotic acid to a choline-deficient diet lowered the incidence of hemorrhagic renal necrosis in young rats from 86% to 41%, and within 24 hr prevented the accumulation of hepatic triglycerides by almost 50%. Simultaneous supplementation of the diet with 0.25% adenine sulfate di...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1968-12, Vol.129 (3), p.874-877
Hauptverfasser: Simon, Jerome B., Scheig, Robert, Klatskin, Gerald
Format: Artikel
Sprache:eng
Schlagworte:
Adenine - pharmacology
Animals
Choline Deficiency
Fatty Liver
Hemorrhage
Kidney
Liver - analysis
Male
Necrosis
Orotic Acid - pharmacology
Rats
Triglycerides - analysis
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Zusammenfassung:Summary Addition of 1% orotic acid to a choline-deficient diet lowered the incidence of hemorrhagic renal necrosis in young rats from 86% to 41%, and within 24 hr prevented the accumulation of hepatic triglycerides by almost 50%. Simultaneous supplementation of the diet with 0.25% adenine sulfate did not influence these protective effects of orotic acid in choline deficiency.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-129-33447