Heterocyclic Amines V. Electrophilic Substitution in Some Carbamate Derivatives of 3-Aminothiophene

Heterocyclic Amines V. Electrophilic Substitution in Some Carbamate Derivatives of 3-Aminothiophene

t-Butyl N-(3-thienyl)carbamate has been brominated, and neopentyl N-(3-thienyl) carbamate has been chlorinated, brominated, iodinated, acetylated, nitrated, and coupled with a diazonium salt. In all cases the incoming substituent was shown by NMR spectrum to be in the 2-position.

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Veröffentlicht in:Journal of pharmaceutical sciences 1968-11, Vol.57 (11), p.2003-2005
Hauptverfasser: Brunett, Emery W., McCarthy, Walter C.
Format: Artikel
Sprache:eng
Schlagworte:
3-Aminothiophene carbamates-electrophilic substitution
Carbamates - chemical synthesis
Diazonium Compounds
Heterocyclic amines
Magnetic Resonance Spectroscopy
NMR spectroscopy-structure
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Zusammenfassung:t-Butyl N-(3-thienyl)carbamate has been brominated, and neopentyl N-(3-thienyl) carbamate has been chlorinated, brominated, iodinated, acetylated, nitrated, and coupled with a diazonium salt. In all cases the incoming substituent was shown by NMR spectrum to be in the 2-position.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600571142