Xanthurenic Acid Dehydroxylation by Fecal Microflora

Xanthurenic Acid Dehydroxylation by Fecal Microflora

Summary In vitro dehydroxylation of xanthurenic acid has been demonstrated in an artificial cecum charged with rabbit fecal fluid. The dehydroxylated product, 8-hy-droxyquinaldic acid, was isolated and crystallized. The results clearly indicate that intestinal microorganisms are responsible for the...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-11, Vol.120 (2), p.546-548
Hauptverfasser: Booth, A. N., Robbins, D. J., Jones, F. T., Emerson, O. H., Masri, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cecum - metabolism
Chromatography, Paper
Feces
Humans
In Vitro Techniques
Intestinal Mucosa - metabolism
Kynurenic Acid - metabolism
Quinolines - metabolism
Rabbits
Rats
Sheep
Xanthurenates - metabolism
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Zusammenfassung:Summary In vitro dehydroxylation of xanthurenic acid has been demonstrated in an artificial cecum charged with rabbit fecal fluid. The dehydroxylated product, 8-hy-droxyquinaldic acid, was isolated and crystallized. The results clearly indicate that intestinal microorganisms are responsible for the dehydroxylation reaction. Dehydroxylation of kynurenic acid to produce quinaldic acid was only qualitatively detectable in the same system.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-120-30585