An albumin and gamma-globulin characteristic of bovine cerebrospinal fluid

Immunoelectrophoretic experiments using a rabbit antiserum to bovine CSF to develop the patterns have shown that a characteristic albumin and a γ-globulin exist in bovine CSF. Both proteins can also be demonstrated in saline extracts of calf brain. This finding suggests that certain as yet unknown neurosecretory cells of the brain are the source of these proteins. The bovine γc-globulin is analogous to the γc-globulin of human CSF in that it exists in two molecular forms with different electrophoretic mobilities but the same immunologic specificities. From visual inspection of the immunoelectrophoretic patterns of CSF from immature and mature animals, it would appear that the CSF of the young animal contains more γc-globulin and less γG-globulin than the CSF of the adult.