The Interaction Between Cholestyramine and Drugs

The Interaction Between Cholestyramine and Drugs

Summary A study was made of the in vitro and in vivo interaction between cholestyramine resin and several commonly used, orally administered drugs. Basic and neutral substances were bound only weakly, if at all, in vitro. Also, many anionic drugs were not strongly bound by cholestyramine, and the ga...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-10, Vol.120 (1), p.60-65
Hauptverfasser: Gallo, D. G., Bailey, K. R., Sheffner, A. L.
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Animals
Aspirin - metabolism
Bile Acids and Salts - metabolism
Blood
Chlorothiazide - metabolism
Cholestyramine Resin - pharmacology
Dogs
Intestinal Absorption
Nicotinic Acids - metabolism
Phenobarbital - metabolism
Phenylbutazone - metabolism
Quinidine - metabolism
Rats
Spectrophotometry
Tetracycline - metabolism
Urine
Warfarin - metabolism
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Beschreibung
Zusammenfassung:Summary A study was made of the in vitro and in vivo interaction between cholestyramine resin and several commonly used, orally administered drugs. Basic and neutral substances were bound only weakly, if at all, in vitro. Also, many anionic drugs were not strongly bound by cholestyramine, and the gastrointestinal absorption of those drugs which were strongly bound was only moderately delayed by concurrent administration of a single dose of resin.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-120-30443