Leukocyte Alkaline Phosphatase: Electrophoretic Variants Associated with Chronic Myelogenous Leukemia

Leukocyte Alkaline Phosphatase: Electrophoretic Variants Associated with Chronic Myelogenous Leukemia

Starch-gel electrophoresis of leukocyte alkaline phosphatases, rendered soluble by treating normal leukocytes with butanol, revealed three electrophoretic variants of the enzyme. The phosphatases in similarly prepared extracts of leukemia cells differed from the normal isozymes in electrophoretic mo...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-10, Vol.150 (3692), p.58-60
Hauptverfasser: Robinson, J. C., Pierce, J. E., Goldstein, Donald P.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline Phosphatase
Chromosomes
Chronic myeloid leukemia
Electrophoresis
Enzymes
Genes
Humans
In Vitro Techniques
Leukemia
Leukemia, Myeloid - genetics
Leukemia, Myeloid - metabolism
Leukocytes
Leukocytes - enzymology
Middle Aged
Phosphatases
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Zusammenfassung:Starch-gel electrophoresis of leukocyte alkaline phosphatases, rendered soluble by treating normal leukocytes with butanol, revealed three electrophoretic variants of the enzyme. The phosphatases in similarly prepared extracts of leukemia cells differed from the normal isozymes in electrophoretic mobility. A single variant was detected in one case of untreated leukemia; a similar component and three additional ones were seen in leukemia treated with 6-mercaptopurine.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.150.3692.58