Studies of Human C-Reactive Protein in an in Vitro Phagocytic System

The interaction of human C-reactive protein and phagocytic mechanisms was studied using an in vitro phagocytosis assay with human polymorphonuclear leukocytes, isolated γG opsonins, or various opsonic serum fractions and living bacteria. No consistent phagocytosis potentiating or blocking effect was...

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Veröffentlicht in:	The Journal of immunology (1950) 1968-09, Vol.101 (3), p.426-432
Hauptverfasser:	Williams, Ralph C., Jr, Quie, Paul G
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Blood Proteins - pharmacology Centrifugation gamma-Globulins Humans In Vitro Techniques Leukocytes - immunology Opsonin Proteins - antagonists & inhibitors Opsonin Proteins - blood Phagocytosis - drug effects Staphylococcus - immunology
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Zusammenfassung:	The interaction of human C-reactive protein and phagocytic mechanisms was studied using an in vitro phagocytosis assay with human polymorphonuclear leukocytes, isolated γG opsonins, or various opsonic serum fractions and living bacteria. No consistent phagocytosis potentiating or blocking effect was seen with isolated human C-reactive protein either added to the phagocytic mixtures or after preincubation with either bacteria or fresh serum fractions.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.101.3.426