The metabolism of the 5-7-dibromo-8-hydroxyquinoline (Broxyquinoline) in man

The urinary elimination in man of a single dose of 2 g of 5-7-dibromo-8-hydroxyquinoline (Broxyquinoline) amounts to 36 molar % after 24 hr and 48 molar % after 72 hr. The main metabolite consists on a glucuronide of the Broxyquinoline, probably an O.glucuronide, which represents about 98 per cent of the urinary metabolites found. Unchanged Broxyquinoline is excreted as a free compound but in very small quantities. Less than 1.3 molar % of the 8-hydroxyquinoline was found, showing that debromination by this way is an unimportant reaction. The elimination rate seems to be controlled by the conjugation process and limited to about 33 mg of Broxyquinoline/hr.