Thiopental Pharmacokinetics
A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum al...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-08, Vol.57 (8), p.1346-1351 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 1351 |
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| container_issue | 8 |
| container_start_page | 1346 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 57 |
| creator | Bischoff, K.B. Dedrick, R.L. |
| description | A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. Metabolism is represented by a Michaelis-Menten rate equation. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations. |
| doi_str_mv | 10.1002/jps.2600570814 |
| format | Article |
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Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. Metabolism is represented by a Michaelis-Menten rate equation. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600570814</identifier><identifier>PMID: 5677337</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Kinetics ; Lipid Metabolism ; mathematical-thiopental distribution ; Model, mathematical—thiopental distribution ; Models, Biological ; Pharmacokinetics-thiopental ; Protein binding-thiopental ; Proteins - metabolism ; Thiopental - metabolism ; Thiopental-distribution</subject><ispartof>Journal of pharmaceutical sciences, 1968-08, Vol.57 (8), p.1346-1351</ispartof><rights>1968 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-2197524ed285ae3579c5a1377790bcb55cb94d4b40223bbee2cc544f91ea0c353</citedby><cites>FETCH-LOGICAL-c4274-2197524ed285ae3579c5a1377790bcb55cb94d4b40223bbee2cc544f91ea0c353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600570814$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600570814$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5677337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischoff, K.B.</creatorcontrib><creatorcontrib>Dedrick, R.L.</creatorcontrib><title>Thiopental Pharmacokinetics</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. Metabolism is represented by a Michaelis-Menten rate equation. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.</description><subject>Kinetics</subject><subject>Lipid Metabolism</subject><subject>mathematical-thiopental distribution</subject><subject>Model, mathematical—thiopental distribution</subject><subject>Models, Biological</subject><subject>Pharmacokinetics-thiopental</subject><subject>Protein binding-thiopental</subject><subject>Proteins - metabolism</subject><subject>Thiopental - metabolism</subject><subject>Thiopental-distribution</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLxEAUhBtRdFyuXkTw5C1jby-dHHXQcUMHHBW8NJ3OG2zNZnfG5d8byaB4EE_vUF8Vr4qQbUaHjFJ-8NSEIY8pBUUTJpfIgAGnUUyZWiaDDuCRAJmukfUQniilMQVYJasQKyWEGpCd6aOrG6xaU-xNHo0vja2fXYWts2GTrMxMEXBrcTfI7cnxdHQaXV6Pz0aHl5GVXMmIs1QBl5jzBAwKUKkFw4RSKqWZzQBslspcZrJ7RmQZIrcWpJylDA21AsQG2e9zG1-_zDG0unTBYlGYCut50IlMgUOcdOCwB62vQ_A40413pfEfmlH9tYbu1tA_a3SG3UXyPCsx_8YX9Ts97fU3V-DHP2n6fHLzKzvqvS60-P7tNf5Zx0oo0PdXY316xC4SwR_0XccnPY_dlK8OvQ7WYWUxdx5tq_Pa_VXjE_sji0k</recordid><startdate>196808</startdate><enddate>196808</enddate><creator>Bischoff, K.B.</creator><creator>Dedrick, R.L.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196808</creationdate><title>Thiopental Pharmacokinetics</title><author>Bischoff, K.B. ; Dedrick, R.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-2197524ed285ae3579c5a1377790bcb55cb94d4b40223bbee2cc544f91ea0c353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Kinetics</topic><topic>Lipid Metabolism</topic><topic>mathematical-thiopental distribution</topic><topic>Model, mathematical—thiopental distribution</topic><topic>Models, Biological</topic><topic>Pharmacokinetics-thiopental</topic><topic>Protein binding-thiopental</topic><topic>Proteins - metabolism</topic><topic>Thiopental - metabolism</topic><topic>Thiopental-distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bischoff, K.B.</creatorcontrib><creatorcontrib>Dedrick, R.L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bischoff, K.B.</au><au>Dedrick, R.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thiopental Pharmacokinetics</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1968-08</date><risdate>1968</risdate><volume>57</volume><issue>8</issue><spage>1346</spage><epage>1351</epage><pages>1346-1351</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. Metabolism is represented by a Michaelis-Menten rate equation. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5677337</pmid><doi>10.1002/jps.2600570814</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1968-08, Vol.57 (8), p.1346-1351 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84952568 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Kinetics Lipid Metabolism mathematical-thiopental distribution Model, mathematical—thiopental distribution Models, Biological Pharmacokinetics-thiopental Protein binding-thiopental Proteins - metabolism Thiopental - metabolism Thiopental-distribution |
| title | Thiopental Pharmacokinetics |
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