Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant

Abstract Background and aims Rare (611C) and common (1062V) variants of the Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) display reduced activation of Wnt/ß-catenin signaling. The rare gene variant was associated with hypertension, metabolic abnormalities, and early coronary artery dise...

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Veröffentlicht in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2011-02, Vol.21 (2), p.150-156
Hauptverfasser:	Sarzani, R, Salvi, F, Bordicchia, M, Guerra, F, Battistoni, I, Pagliariccio, G, Carbonari, L, Dessì-Fulgheri, P, Rappelli, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alleles atherosclerosis beta Catenin - genetics beta Catenin - metabolism Cardiovascular carotid arteries Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid atherosclerosis coronary artery disease fasting Female Gene Expression Genetics genotype glomerular filtration rate glucose Humans hyperlipidemia Hypertension Hypertension - genetics Hypertension - metabolism LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - metabolism Lipoprotein receptor-related protein 6 Logistic Models low density lipoprotein Low Density Lipoprotein Receptor-Related Protein-6 Male Middle Aged noninsulin-dependent diabetes mellitus patients Plaque, Atherosclerotic - metabolism regression analysis Retrospective Studies Risk Factors Signal Transduction smoking (habit) ultrasonography Wnt Proteins - genetics Wnt Proteins - metabolism Wnt/β-catenin
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Zusammenfassung:	Abstract Background and aims Rare (611C) and common (1062V) variants of the Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) display reduced activation of Wnt/ß-catenin signaling. The rare gene variant was associated with hypertension, metabolic abnormalities, and early coronary artery disease. We investigated whether the common 1062V LRP6 variant was related to carotid artery atherosclerosis (CAA) in hypertensive patients. Methods and results Retrospective study of 334 hypertensive patients (
ISSN:	0939-4753 1590-3729
DOI:	10.1016/j.numecd.2009.08.004