Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23

Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23

Recent genome-wide association (GWA) studies identified 10 chromosomal loci for coronary artery disease (CAD) or myocardial infarction (MI). However, these loci explain only a small proportion of the genetic variability of these pertinent diseases. We sought to identify additional CAD/MI loci by app...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European heart journal 2011-01, Vol.32 (2), p.158-168
Hauptverfasser: ERDMANN, Jeanette, WILLENBORG, Christina, AHERRAHROU, Zouhair, KLOPP, Norman, LOLEY, Christina, STARK, Klaus, HENGSTENBERG, Christian, BRUSE, Petra, FREYER, Jennifer, WAGNER, Arnika K, MEDACK, Anja, LIEB, Wolfgang, NAHRSTAEDT, Janja, GROSSHENNIG, Anika, SAGER, Hendrik B, REINHARDT, Adrian, SCHÄFER, Arne, SCHREIBER, Stefan, EDDINE EL MOKHTARI, Nour, RAAZ-SCHRAUDER, Dorette, ILLIG, Thomas, GARLICHS, Christoph D, EKICI, Arif B, PREUSS, Michael, REIS, André, SCHREZENMEIR, Jürgen, RUBIN, Diana, ZIEGLER, Andreas, WICHMANN, H.-E, DOERING, Angela, MEISINGER, Christa, MEITINGER, Thomas, PETERS, Annette, SCHUNKERT, Heribert, KÖNIG, Inke R, BAUMERT, Jens, LINSEL-NITSCHKE, Patrick, GIEGER, Christian, TENNSTEDT, Stephanie, BELCREDI, Petra
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Cardiology. Vascular system
Cell Adhesion Molecules - genetics
Chromosomes, Human, Pair 10 - genetics
Chromosomes, Human, Pair 9 - genetics
Coronary Artery Disease - genetics
Coronary heart disease
Female
Genome-Wide Association Study
Genotype
Genotyping Techniques - methods
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - genetics
Myocarditis. Cardiomyopathies
Pedigree
Polymorphism, Single Nucleotide - genetics
Risk Factors
Young Adult
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Recent genome-wide association (GWA) studies identified 10 chromosomal loci for coronary artery disease (CAD) or myocardial infarction (MI). However, these loci explain only a small proportion of the genetic variability of these pertinent diseases. We sought to identify additional CAD/MI loci by applying a three-stage approach. We genotyped n = 1157 MI cases and n = 1748 controls from a population-based study population [German MI Family Study (GerMIFS) III (KORA)] with genome-wide SNP arrays. At this first stage, n = 462 SNPs showed association with MI at P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehq405