Possible Mechanism for Mycoplasma Inhibition of Lymphocyte Transformation induced by Phytohaemagglutinin

Possible Mechanism for Mycoplasma Inhibition of Lymphocyte Transformation induced by Phytohaemagglutinin

Mycoplasma pneumoniae stimulates transformation and mitosis in cultures of lymphocytes obtained from sensitized individuals 1 , as do other antigens 2 . In contrast, M. hominis 3 and M. arthritidis 4 inhibit lymphocyte transformation induced by phytohaemagglutinin (PHA). We have examined the effects...

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Veröffentlicht in:Nature (London) 1968-08, Vol.219 (5155), p.751-752
Hauptverfasser: BARILE, MICHAEL F., LEVENTHAL, BRIGID G.
Format: Artikel
Sprache:eng
Schlagworte:
Arginine - pharmacology
Cell Differentiation
Culture Media
Culture Techniques
Humanities and Social Sciences
Humans
Lectins - pharmacology
letter
Lymphocytes - cytology
Lymphocytes - drug effects
multidisciplinary
Mycoplasma - metabolism
Science
Science (multidisciplinary)
Stimulation, Chemical
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Zusammenfassung:Mycoplasma pneumoniae stimulates transformation and mitosis in cultures of lymphocytes obtained from sensitized individuals 1 , as do other antigens 2 . In contrast, M. hominis 3 and M. arthritidis 4 inhibit lymphocyte transformation induced by phytohaemagglutinin (PHA). We have examined the effects of different species of Mycoplasma on lymphocyte cultures in an attempt to elucidate the mechanism of mycoplasma inhibition of PHA-induced transformation.
ISSN:0028-0836
1476-4687
DOI:10.1038/219751a0