Absence of 16α-hydroxylating activity in the human midterm placenta

Absence of 16α-hydroxylating activity in the human midterm placenta

Testosterone-4- 14C was incubated with homogenates of three midterm placentas. Although large quantities of 14C-labeled estrone and 17β-estradiol were isolated, no 14C-labeled estriol was detected. These findings agree with the results of in situ placental perfusions previously reported from this la...

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Veröffentlicht in:Steroids 1968-06, Vol.11 (6), p.877-884
Hauptverfasser: Jackanicz, T.M., Diczfalusy, E.
Format: Artikel
Sprache:eng
Schlagworte:
Carbon Isotopes
Chromatography, Paper
Estradiol - metabolism
Estriol - metabolism
Estrone - metabolism
Female
Humans
In Vitro Techniques
Placenta - enzymology
Placenta - metabolism
Pregnancy
Testosterone - metabolism
Tritium
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Zusammenfassung:Testosterone-4- 14C was incubated with homogenates of three midterm placentas. Although large quantities of 14C-labeled estrone and 17β-estradiol were isolated, no 14C-labeled estriol was detected. These findings agree with the results of in situ placental perfusions previously reported from this laboratory. It is concluded that the human placenta at midpregnancy does not possess a 16α-hydroxylating enzyme system for C-19 and C-18 steroids.
ISSN:0039-128X
1878-5867
DOI:10.1016/S0039-128X(68)80101-1