California group arboviruses: Electron microscopic studies

Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in associa...

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Veröffentlicht in:	Experimental and molecular pathology 1968-01, Vol.9 (1), p.44-56
Hauptverfasser:	Murphy, Frederick A., Whitfield, Sylvia G., Coleman, Philip H., Calisher, Charles H., Rabin, Erwin R., Bennett Jenson, A., Melnick, Joseph L., Edwards, Mercedes R., Whitney, Elinor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arbovirus Infections - microbiology Arboviruses - pathogenicity Brain - microbiology Complement Fixation Tests Culture Techniques Cytopathogenic Effect, Viral Hemagglutination Tests Immunodiffusion Inclusion Bodies, Viral Mice Microscopy, Electron Neurons - microbiology
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Zusammenfassung:	Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.
ISSN:	0014-4800 1096-0945
DOI:	10.1016/0014-4800(68)90049-X