Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing seroton...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1968-08, Vol.161 (3842), p.706-708
Hauptverfasser: Aghajanian, George K., Foote, Warren E., Sheard, Michael H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain
Cell nucleus
Dosage
Electric Stimulation
Electrodes
Evoked Potentials
Feedback
Intravenous injections
LSD
Lysergic Acid Diethylamide - pharmacology
Male
Mesencephalon - metabolism
Metabolism
Midbrain
Neurons
Neurons - drug effects
Neurons - metabolism
Neurons - physiology
Raphe nuclei
Rats
Serotonin - metabolism
Stereotaxic Techniques
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Zusammenfassung:Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.161.3842.706