Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas

Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas

Spirocurcasone (14), a diterpenoid possessing the unprecedented “spirorhamnofolane” skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was establ...

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Veröffentlicht in:Organic letters 2011-01, Vol.13 (2), p.316-319
Hauptverfasser: Chianese, Giuseppina, Fattorusso, Ernesto, Aiyelaagbe, Olapeju O, Luciano, Paolo, Schröder, Heinz C, Müller, Werner E. G, Taglialatela-Scafati, Orazio
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Drug Screening Assays, Antitumor
Jatropha - chemistry
Mice
Molecular Structure
Plant Bark - chemistry
Plant Roots - chemistry
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Zusammenfassung:Spirocurcasone (14), a diterpenoid possessing the unprecedented “spirorhamnofolane” skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102802u