Influence of Cyclodextrins on Ester Hydrolysis
The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclod...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-01, Vol.57 (1), p.44-48 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 57 |
| creator | Chin, Ting-Fong Chung, Ping-Hong Lach, John L. |
| description | The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclodextrin are primarily responsible for these catalytic and inhibitory effects observed. |
| doi_str_mv | 10.1002/jps.2600570109 |
| format | Article |
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It is also shown that the stereochemistry of binding and the degree of ionization of cyclodextrin are primarily responsible for these catalytic and inhibitory effects observed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600570109</identifier><identifier>PMID: 5661767</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Acetylsalicylic acid hydrolysis catalyzed by cyclodextrins ; Aminobenzoates ; and meta) aminobenzoates hydrolysis decelerated by cyclodextrins ; Aspirin ; Atropine ; Atropine hydrolysis catalyzed by cyclodextrins ; Catalysis ; Chemical Phenomena ; Chemistry ; Cylodextrins influence on alkaline hydrolysis of esters ; Ester hydrolysis ; Ethyl-(para ; Ethyl-(para, ortho, and meta) aminobenzoates hydrolysis decelerated by cyclodextrins ; Ions ; ortho ; Polysaccharides ; Spectrophotometry ; UV spectrophotometry-analysis</subject><ispartof>Journal of pharmaceutical sciences, 1968-01, Vol.57 (1), p.44-48</ispartof><rights>1968 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4279-c4436ebedfa6b3c497812e02411522278215b4932728dabea18173db1f7e48c13</citedby><cites>FETCH-LOGICAL-c4279-c4436ebedfa6b3c497812e02411522278215b4932728dabea18173db1f7e48c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600570109$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600570109$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5661767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chin, Ting-Fong</creatorcontrib><creatorcontrib>Chung, Ping-Hong</creatorcontrib><creatorcontrib>Lach, John L.</creatorcontrib><title>Influence of Cyclodextrins on Ester Hydrolysis</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclodextrin are primarily responsible for these catalytic and inhibitory effects observed.</description><subject>Acetylsalicylic acid hydrolysis catalyzed by cyclodextrins</subject><subject>Aminobenzoates</subject><subject>and meta) aminobenzoates hydrolysis decelerated by cyclodextrins</subject><subject>Aspirin</subject><subject>Atropine</subject><subject>Atropine hydrolysis catalyzed by cyclodextrins</subject><subject>Catalysis</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Cylodextrins influence on alkaline hydrolysis of esters</subject><subject>Ester hydrolysis</subject><subject>Ethyl-(para</subject><subject>Ethyl-(para, ortho, and meta) aminobenzoates hydrolysis decelerated by cyclodextrins</subject><subject>Ions</subject><subject>ortho</subject><subject>Polysaccharides</subject><subject>Spectrophotometry</subject><subject>UV spectrophotometry-analysis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9LwzAYhoMoc06v3oSevHUmaZO0Rxn7JUMFpw4voU2_QmbXzmTV9b83o2PiQbwkh-95X_I9QeiS4D7BmN4s17ZPOcZMYILjI9QljGKfYyKOUdcB1A9YGJ-iM2uXGGOOGeugDuOcCC66qD8t86KGUoFX5d6gUUWVwXZjdGm9qvSGdgPGmzSZqYrGanuOTvKksHCxv3voeTScDyb-7GE8HdzOfBVSEbszDDikkOUJTwMVxiIiFDANiXsdpSKihKVhHFBBoyxJISEREUGWklxAGCkS9NB127s21UcNdiNX2iooiqSEqrYyCqOYEY4d2G9BZSprDeRybfQqMY0kWO4ESSdI_ghygat9c52uIDvgeyNuHrfzL11A80-bvHt8-tXtt1nttG0P2cS8S9csmHy9H8uXt8VoMl8M5MTxUcuDU_mpwUir9O4vMm1AbWRW6b_W-AZCiZI3</recordid><startdate>196801</startdate><enddate>196801</enddate><creator>Chin, Ting-Fong</creator><creator>Chung, Ping-Hong</creator><creator>Lach, John L.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196801</creationdate><title>Influence of Cyclodextrins on Ester Hydrolysis</title><author>Chin, Ting-Fong ; Chung, Ping-Hong ; Lach, John L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4279-c4436ebedfa6b3c497812e02411522278215b4932728dabea18173db1f7e48c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Acetylsalicylic acid hydrolysis catalyzed by cyclodextrins</topic><topic>Aminobenzoates</topic><topic>and meta) aminobenzoates hydrolysis decelerated by cyclodextrins</topic><topic>Aspirin</topic><topic>Atropine</topic><topic>Atropine hydrolysis catalyzed by cyclodextrins</topic><topic>Catalysis</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Cylodextrins influence on alkaline hydrolysis of esters</topic><topic>Ester hydrolysis</topic><topic>Ethyl-(para</topic><topic>Ethyl-(para, ortho, and meta) aminobenzoates hydrolysis decelerated by cyclodextrins</topic><topic>Ions</topic><topic>ortho</topic><topic>Polysaccharides</topic><topic>Spectrophotometry</topic><topic>UV spectrophotometry-analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chin, Ting-Fong</creatorcontrib><creatorcontrib>Chung, Ping-Hong</creatorcontrib><creatorcontrib>Lach, John L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chin, Ting-Fong</au><au>Chung, Ping-Hong</au><au>Lach, John L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Cyclodextrins on Ester Hydrolysis</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1968-01</date><risdate>1968</risdate><volume>57</volume><issue>1</issue><spage>44</spage><epage>48</epage><pages>44-48</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclodextrin are primarily responsible for these catalytic and inhibitory effects observed.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5661767</pmid><doi>10.1002/jps.2600570109</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1968-01, Vol.57 (1), p.44-48 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Acetylsalicylic acid hydrolysis catalyzed by cyclodextrins Aminobenzoates and meta) aminobenzoates hydrolysis decelerated by cyclodextrins Aspirin Atropine Atropine hydrolysis catalyzed by cyclodextrins Catalysis Chemical Phenomena Chemistry Cylodextrins influence on alkaline hydrolysis of esters Ester hydrolysis Ethyl-(para Ethyl-(para, ortho, and meta) aminobenzoates hydrolysis decelerated by cyclodextrins Ions ortho Polysaccharides Spectrophotometry UV spectrophotometry-analysis |
| title | Influence of Cyclodextrins on Ester Hydrolysis |
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