Influence of Cyclodextrins on Ester Hydrolysis

The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclod...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1968-01, Vol.57 (1), p.44-48
Hauptverfasser:	Chin, Ting-Fong, Chung, Ping-Hong, Lach, John L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylsalicylic acid hydrolysis catalyzed by cyclodextrins Aminobenzoates and meta) aminobenzoates hydrolysis decelerated by cyclodextrins Aspirin Atropine Atropine hydrolysis catalyzed by cyclodextrins Catalysis Chemical Phenomena Chemistry Cylodextrins influence on alkaline hydrolysis of esters Ester hydrolysis Ethyl-(para Ethyl-(para, ortho, and meta) aminobenzoates hydrolysis decelerated by cyclodextrins Ions ortho Polysaccharides Spectrophotometry UV spectrophotometry-analysis
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Zusammenfassung:	The hydrolysis of various ethyl esters of aminobenzoic acids, acetylsalicylic acid, and atropine in alkaline solution was shown to be either accelerated or decelerated in the presence of α and β-cyclodextrin. It is also shown that the stereochemistry of binding and the degree of ionization of cyclodextrin are primarily responsible for these catalytic and inhibitory effects observed.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600570109