Blood Plasma Levels and Elimination of Salts of 2-PAM in Man After Oral Administration

The absorption and elimination of pralidoxime salts after oral administration to human volunteers have been studied at a dosage of 1.5–10g. of drug for a 70-kg. man. The biological half-life, calculated from blood plasma values and urinary excretion rates, was approximately 1.7hr. A 10-fold increase in dosage of the pralidoxime salts increased the peak plasma level of oxime 3.5-fold. The average total amount of pralidoxime recovered in the urine was 27 percent. In subjects given the iodide salt, symptoms of iodism were observed; all other clinical tests were negative. Some observations were made on the behavior of a bis-quaternary oxime.