McCune-Albright's syndrome following adrenalectomy for Cushing's syndrome in infancy

This report adds a new example to the curious association of polyostotic fibrous dysplasia with various endocrine disorders. A girl developed symptoms of Cushing's syndrome at the age of 1 month. Total bilateral adrenalectomy was carried out when the infant was 4 months of age. Both glands showed nodular adrenal cortical hyperplasia. Within a period of 8 to 44 months following surgery, the clinical picture of McCune-Albright's syndrome became apparent, including skin pigmentation, polyostotic fibrous dysplasia, and sexual precocity.