Studies on the synthesis of cholesterol in the brain of the human fetus
Following the intravenous injection of a single dose of acetate-C14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liv...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1968-06, Vol.101 (4), p.534-538 |
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| container_end_page | 538 |
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| container_issue | 4 |
| container_start_page | 534 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 101 |
| creator | Plotz, E.J. Kabara, J.J. Davis, M.E. LeRoy, G.V. Gordon Gould, R. |
| description | Following the intravenous injection of a single dose of acetate-C14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liver, and fetal adrenals. Neither cholesterol-C14 synthesized in the fetal liver nor maternal plasma cholesterol-H3 of dietary origin was taken up by the fetal brain in appreciable amounts. When glucose-C14 was injected in the mother, the isotope was found in cholesterol isolated from the fetal brain and other fetal tissues but only negligible amounts were found in maternal tissues. The preferential utilization of glucose for the synthesis of fetal brain cholesterol emphasizes the significance of the “blood-brain barrier” which controls the movement of substances into and out of central nervous system tissue. |
| doi_str_mv | 10.1016/0002-9378(68)90565-6 |
| format | Article |
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Neither cholesterol-C14 synthesized in the fetal liver nor maternal plasma cholesterol-H3 of dietary origin was taken up by the fetal brain in appreciable amounts. When glucose-C14 was injected in the mother, the isotope was found in cholesterol isolated from the fetal brain and other fetal tissues but only negligible amounts were found in maternal tissues. 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The preferential utilization of glucose for the synthesis of fetal brain cholesterol emphasizes the significance of the “blood-brain barrier” which controls the movement of substances into and out of central nervous system tissue.</description><subject>Acetates - metabolism</subject><subject>Adrenal Glands - analysis</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - metabolism</subject><subject>Carbon Isotopes - metabolism</subject><subject>Cholesterol - biosynthesis</subject><subject>Corpus Luteum - analysis</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Hydrogen - metabolism</subject><subject>Liver - analysis</subject><subject>Tritium - metabolism</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLxDAQhYMo67r6DxR6Ej1Uk7ZJk4sgi67Cggf1HNJkykbaZk1aYf-9qV326Gne5L2ZJB9ClwTfEUzYPcY4S0Ve8hvGbwWmjKbsCM0JFmXKOOPHaH6InKKzEL7GNhPZDM1imOZCzNHqvR-MhZC4Luk3kIRdF0uw8aBO9MY1EHrwrkns5FdeRRW9sdkMreqSGvohnKOTWjUBLvZ1gT6fnz6WL-n6bfW6fFynOqdln5KaGMOVVlnJCAdRCSYwp4Iww5gwhREVJlxzxaOiQtUl0TgqpTGNqTJfoOtp79a77yE-TrY2aGga1YEbguQF5ywrWAwWU1B7F4KHWm69bZXfSYLlyE-ONOQIRzIu__jJcexqv3-oWjCHoT2w6D9MPsRP_ljwMmgLnQZjPeheGmf_v-AXci9-cQ</recordid><startdate>19680615</startdate><enddate>19680615</enddate><creator>Plotz, E.J.</creator><creator>Kabara, J.J.</creator><creator>Davis, M.E.</creator><creator>LeRoy, G.V.</creator><creator>Gordon Gould, R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19680615</creationdate><title>Studies on the synthesis of cholesterol in the brain of the human fetus</title><author>Plotz, E.J. ; Kabara, J.J. ; Davis, M.E. ; LeRoy, G.V. ; Gordon Gould, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1f1dd8aca27618e9b969085916d669d4d9b018c8a8d9b59af71c09b5ac0559173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Acetates - metabolism</topic><topic>Adrenal Glands - analysis</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - metabolism</topic><topic>Carbon Isotopes - metabolism</topic><topic>Cholesterol - biosynthesis</topic><topic>Corpus Luteum - analysis</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Hydrogen - metabolism</topic><topic>Liver - analysis</topic><topic>Tritium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plotz, E.J.</creatorcontrib><creatorcontrib>Kabara, J.J.</creatorcontrib><creatorcontrib>Davis, M.E.</creatorcontrib><creatorcontrib>LeRoy, G.V.</creatorcontrib><creatorcontrib>Gordon Gould, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plotz, E.J.</au><au>Kabara, J.J.</au><au>Davis, M.E.</au><au>LeRoy, G.V.</au><au>Gordon Gould, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the synthesis of cholesterol in the brain of the human fetus</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1968-06-15</date><risdate>1968</risdate><volume>101</volume><issue>4</issue><spage>534</spage><epage>538</epage><pages>534-538</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Following the intravenous injection of a single dose of acetate-C14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liver, and fetal adrenals. 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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1968-06, Vol.101 (4), p.534-538 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84886246 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetates - metabolism Adrenal Glands - analysis Blood-Brain Barrier - physiology Brain - metabolism Carbon Isotopes - metabolism Cholesterol - biosynthesis Corpus Luteum - analysis Female Fetus - metabolism Glucose - metabolism Humans Hydrogen - metabolism Liver - analysis Tritium - metabolism |
| title | Studies on the synthesis of cholesterol in the brain of the human fetus |
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