Studies on the synthesis of cholesterol in the brain of the human fetus

Following the intravenous injection of a single dose of acetate-C14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liv...

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Veröffentlicht in:American journal of obstetrics and gynecology 1968-06, Vol.101 (4), p.534-538
Hauptverfasser: Plotz, E.J., Kabara, J.J., Davis, M.E., LeRoy, G.V., Gordon Gould, R.
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Sprache:eng
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Zusammenfassung:Following the intravenous injection of a single dose of acetate-C14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liver, and fetal adrenals. Neither cholesterol-C14 synthesized in the fetal liver nor maternal plasma cholesterol-H3 of dietary origin was taken up by the fetal brain in appreciable amounts. When glucose-C14 was injected in the mother, the isotope was found in cholesterol isolated from the fetal brain and other fetal tissues but only negligible amounts were found in maternal tissues. The preferential utilization of glucose for the synthesis of fetal brain cholesterol emphasizes the significance of the “blood-brain barrier” which controls the movement of substances into and out of central nervous system tissue.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(68)90565-6