The Use of 32Di-Isopropylfluorophosphate (32DFP) As A Platelet Label: Evidence for Reutilization of This Isotope In Man
Certain aspects of 32DFP metabolism in man have been studied. It is probable that about 10 per cent of an injected dose is metabolized and reappears in the platelet. This affects the platelet decay curve after day 8 and may influence data on red and white cell kinetics obtained with this isotope. Co...
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| Veröffentlicht in: | Blood 1968-06, Vol.31 (6), p.791-805 |
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| creator | Cooney, D.P. Smith, B.A. Fawley, D.E. |
| description | Certain aspects of 32DFP metabolism in man have been studied. It is probable that about 10 per cent of an injected dose is metabolized and reappears in the platelet. This affects the platelet decay curve after day 8 and may influence data on red and white cell kinetics obtained with this isotope.
Considering the effects of reincorporation of this compound, we have studied twenty normal individuals and have found a mean platelet lifespan of 11.5 days. Statistical analysis supports the concept that the platelet decay curve is linear: platelets are removed from the circulation because of senescence rather than in a random fashion.
The literature on human platelet lifespans is reviewed. Most authors support the concept of a linear decay curve, although the evidence is conflicting and opinions are divided. |
| doi_str_mv | 10.1182/blood.V31.6.791.791 |
| format | Article |
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Considering the effects of reincorporation of this compound, we have studied twenty normal individuals and have found a mean platelet lifespan of 11.5 days. Statistical analysis supports the concept that the platelet decay curve is linear: platelets are removed from the circulation because of senescence rather than in a random fashion.
The literature on human platelet lifespans is reviewed. Most authors support the concept of a linear decay curve, although the evidence is conflicting and opinions are divided.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V31.6.791.791</identifier><identifier>PMID: 5654970</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Autoradiography ; Blood Platelets - analysis ; Blood Platelets - metabolism ; Humans ; Injections, Intravenous ; Isoflurophate - administration & dosage ; Isoflurophate - blood ; Megakaryocytes ; Polycythemia Vera ; Radioisotopes ; Thrombocytopenia</subject><ispartof>Blood, 1968-06, Vol.31 (6), p.791-805</ispartof><rights>1968 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-8a739069f6671658a2b9a672727b948cbe4f62b9f9b89f1fc1bce517a78ad65a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5654970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooney, D.P.</creatorcontrib><creatorcontrib>Smith, B.A.</creatorcontrib><creatorcontrib>Fawley, D.E.</creatorcontrib><title>The Use of 32Di-Isopropylfluorophosphate (32DFP) As A Platelet Label: Evidence for Reutilization of This Isotope In Man</title><title>Blood</title><addtitle>Blood</addtitle><description>Certain aspects of 32DFP metabolism in man have been studied. It is probable that about 10 per cent of an injected dose is metabolized and reappears in the platelet. This affects the platelet decay curve after day 8 and may influence data on red and white cell kinetics obtained with this isotope.
Considering the effects of reincorporation of this compound, we have studied twenty normal individuals and have found a mean platelet lifespan of 11.5 days. Statistical analysis supports the concept that the platelet decay curve is linear: platelets are removed from the circulation because of senescence rather than in a random fashion.
The literature on human platelet lifespans is reviewed. Most authors support the concept of a linear decay curve, although the evidence is conflicting and opinions are divided.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoradiography</subject><subject>Blood Platelets - analysis</subject><subject>Blood Platelets - metabolism</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Isoflurophate - administration & dosage</subject><subject>Isoflurophate - blood</subject><subject>Megakaryocytes</subject><subject>Polycythemia Vera</subject><subject>Radioisotopes</subject><subject>Thrombocytopenia</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9rGzEQxUVpSNy0nyAEdCrpYR1p_2ilQA4msVODQ0OxcxVa7QgryKvNatch_fTV1qbHIAYN7808mB9CF5RMKeXpdeW8r6fPGZ2yaSnoWJ_QhBYpTwhJyWc0IYSwJBclPUNfQnghhOZZWpyi04IVUSYT9LbeAt4EwN7gLL23yTL4tvPtuzNu8LHZ-tBuVQ_4KtqLpx94FvAMP7koOejxSlXgbvB8b2toNGDjO_wbht46-0f11jdj8HprA47BvW8BLxv8qJqv6MQoF-Db8T9Hm8V8ffczWf16WN7NVonOhOgTrspMECYMYyVlBVdpJRQr0_gqkXNdQW5Y1IyouDDUaFppKGipSq5qVqjsHH0_5MajXgcIvdzZoME51YAfguQ555QSGgezw6DufAgdGNl2dqe6d0mJHHHLf7hlxC2ZjKjHiluXx_ih2kH9f-fIN_q3Bx_ijXsLnQzajqBq24HuZe3th_l_AQw4kLs</recordid><startdate>196806</startdate><enddate>196806</enddate><creator>Cooney, D.P.</creator><creator>Smith, B.A.</creator><creator>Fawley, D.E.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196806</creationdate><title>The Use of 32Di-Isopropylfluorophosphate (32DFP) As A Platelet Label: Evidence for Reutilization of This Isotope In Man</title><author>Cooney, D.P. ; Smith, B.A. ; Fawley, D.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-8a739069f6671658a2b9a672727b948cbe4f62b9f9b89f1fc1bce517a78ad65a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoradiography</topic><topic>Blood Platelets - analysis</topic><topic>Blood Platelets - metabolism</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Isoflurophate - administration & dosage</topic><topic>Isoflurophate - blood</topic><topic>Megakaryocytes</topic><topic>Polycythemia Vera</topic><topic>Radioisotopes</topic><topic>Thrombocytopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooney, D.P.</creatorcontrib><creatorcontrib>Smith, B.A.</creatorcontrib><creatorcontrib>Fawley, D.E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooney, D.P.</au><au>Smith, B.A.</au><au>Fawley, D.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Use of 32Di-Isopropylfluorophosphate (32DFP) As A Platelet Label: Evidence for Reutilization of This Isotope In Man</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1968-06</date><risdate>1968</risdate><volume>31</volume><issue>6</issue><spage>791</spage><epage>805</epage><pages>791-805</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Certain aspects of 32DFP metabolism in man have been studied. It is probable that about 10 per cent of an injected dose is metabolized and reappears in the platelet. This affects the platelet decay curve after day 8 and may influence data on red and white cell kinetics obtained with this isotope.
Considering the effects of reincorporation of this compound, we have studied twenty normal individuals and have found a mean platelet lifespan of 11.5 days. Statistical analysis supports the concept that the platelet decay curve is linear: platelets are removed from the circulation because of senescence rather than in a random fashion.
The literature on human platelet lifespans is reviewed. Most authors support the concept of a linear decay curve, although the evidence is conflicting and opinions are divided.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5654970</pmid><doi>10.1182/blood.V31.6.791.791</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 1968-06, Vol.31 (6), p.791-805 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84881101 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Autoradiography Blood Platelets - analysis Blood Platelets - metabolism Humans Injections, Intravenous Isoflurophate - administration & dosage Isoflurophate - blood Megakaryocytes Polycythemia Vera Radioisotopes Thrombocytopenia |
| title | The Use of 32Di-Isopropylfluorophosphate (32DFP) As A Platelet Label: Evidence for Reutilization of This Isotope In Man |
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