Influence of adsorbents in transdermal matrix patches on the release and the physical state of ethinyl estradiol and levonorgestrel

Adsorbents in transdermal matrix systems. The drug release from medium molecular weight polyisobutene patches containing adsorbates (drug content: 0.2% ethinyl estradiol, 1.0% levonorgestrel; adsorbent content: 20%, w/w) increased in the order of no adsorbent

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2011-02, Vol.77 (2), p.240-248
Hauptverfasser:	Schulz, Martin, Fussnegger, Bernhard, Bodmeier, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbent Administration, Cutaneous Adsorption Biological and medical sciences Contraceptive Agents, Female - administration & dosage Contraceptive Agents, Female - chemistry Contraceptive Agents, Female - pharmacokinetics Crospovidone Crystallization Delayed-Action Preparations Drug Compounding Drug recrystallization Estrogens - administration & dosage Estrogens - chemistry Estrogens - pharmacokinetics Ethinyl estradiol Ethinyl Estradiol - administration & dosage Ethinyl Estradiol - chemistry Ethinyl Estradiol - pharmacokinetics General pharmacology Humans Levonorgestrel Levonorgestrel - administration & dosage Levonorgestrel - chemistry Levonorgestrel - pharmacokinetics Medical sciences Molecular Weight Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Povidone - chemistry Solubility Transdermal drug delivery Transdermal Patch Water
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Beschreibung
Zusammenfassung:	Adsorbents in transdermal matrix systems. The drug release from medium molecular weight polyisobutene patches containing adsorbates (drug content: 0.2% ethinyl estradiol, 1.0% levonorgestrel; adsorbent content: 20%, w/w) increased in the order of no adsorbent
ISSN:	0939-6411 1873-3441
DOI:	10.1016/j.ejpb.2010.11.011