Treatment of Acyclovir-Resistant Herpes Simplex Virus with Continuous Infusion of High-Dose Acyclovir in Hematopoietic Cell Transplant Patients

Infection because of herpes simplex virus (HSV) that is resistant to acyclovir (ACV) poses treatment challenges in hematopoietic cell transplant (HCT) patients. We present a series of patients with ACV-resistant HSV following HCT who were successfully treated with continuous infusion high-dose ACV a...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2011-02, Vol.17 (2), p.259-264
Hauptverfasser:	Kim, Janet H, Schaenman, Joanna M, Ho, Dora Y, Brown, Janice M.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir Acyclovir - administration & dosage Acyclovir - adverse effects Acyclovir - therapeutic use Adult Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Drug resistance Drug Resistance, Multiple, Viral Drug Resistance, Viral Female Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation Herpes Simplex - drug therapy Humans Immunocompromised Host Infusions, Intravenous Male Middle Aged Simplexvirus - drug effects Simplexvirus - isolation & purification Treatment Outcome
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Zusammenfassung:	Infection because of herpes simplex virus (HSV) that is resistant to acyclovir (ACV) poses treatment challenges in hematopoietic cell transplant (HCT) patients. We present a series of patients with ACV-resistant HSV following HCT who were successfully treated with continuous infusion high-dose ACV after failing standard treatment regimens for ACV-resistant HSV.
ISSN:	1083-8791 1523-6536
DOI:	10.1016/j.bbmt.2010.06.020