Equilibrium Phenomena in Solid Dosage Forms
Certain aspects of the mechanics of drug decay in solid dosage forms are discussed. Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fair...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-01, Vol.57 (1), p.23-27 |
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| container_end_page | 27 |
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| container_issue | 1 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 57 |
| creator | Thurø Carstensen, J. Johnson, J.B. Spera, D.C. Frank, M.J. |
| description | Certain aspects of the mechanics of drug decay in solid dosage forms are discussed. Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fairly stable drugs, to assay for degradation products. Van't Hoff plots should be used in this case. |
| doi_str_mv | 10.1002/jps.2600570104 |
| format | Article |
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Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fairly stable drugs, to assay for degradation products. Van't Hoff plots should be used in this case.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600570104</identifier><identifier>PMID: 5652134</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Chemistry, Pharmaceutical ; Dosage Forms ; Drug Stability ; Drug stability in solid dosage forms ; Equilibrium phenomena ; Mathematics ; Succinates - analysis ; Temperature ; TLC determination of free tocopherol ; UV analysis ; Vitamin A - analysis ; Vitamin A decay ; Vitamin E - analysis ; Vitamin E decay</subject><ispartof>Journal of pharmaceutical sciences, 1968-01, Vol.57 (1), p.23-27</ispartof><rights>1968 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-197a868f814c8c5cc42fba42afb06fee2d770c04e292f8c94665a4eff1438fe53</citedby><cites>FETCH-LOGICAL-c4274-197a868f814c8c5cc42fba42afb06fee2d770c04e292f8c94665a4eff1438fe53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600570104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600570104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5652134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurø Carstensen, J.</creatorcontrib><creatorcontrib>Johnson, J.B.</creatorcontrib><creatorcontrib>Spera, D.C.</creatorcontrib><creatorcontrib>Frank, M.J.</creatorcontrib><title>Equilibrium Phenomena in Solid Dosage Forms</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Certain aspects of the mechanics of drug decay in solid dosage forms are discussed. Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fairly stable drugs, to assay for degradation products. Van't Hoff plots should be used in this case.</description><subject>Chemistry, Pharmaceutical</subject><subject>Dosage Forms</subject><subject>Drug Stability</subject><subject>Drug stability in solid dosage forms</subject><subject>Equilibrium phenomena</subject><subject>Mathematics</subject><subject>Succinates - analysis</subject><subject>Temperature</subject><subject>TLC determination of free tocopherol</subject><subject>UV analysis</subject><subject>Vitamin A - analysis</subject><subject>Vitamin A decay</subject><subject>Vitamin E - analysis</subject><subject>Vitamin E decay</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LJDEQhoMo7jh69bbQJy_SYyWdpNPHxY9RER1QEbyETLqicftjTKb9-Pe29KDsYfFUUPW8L9RDyC6FCQVgB0-LOGESQORAga-RERUMUgk0XyejHmBpJnjxi2zF-AQAEoTYJJtCCkYzPiL7x8-dr_w8-K5OZo_YtDU2JvFNct1WvkyO2mgeMDlpQx23yYYzVcSd1RyT25Pjm8PT9OJqenb45yK1nOU8pUVulFROUW6VFbbfurnhzLg5SIfIyjwHCxxZwZyyBZdSGI7OUZ4phyIbk72hdxHa5w7jUtc-Wqwq02DbRa24klwWWQ9OBtCGNsaATi-Cr0141xT0px3d29HfdvrA71VzN6-x_MJXOvp7MdxffYXvP7Tp89n1P93pkPVxiW9fWRP-aplnudB3l1Mt6L0CdT_Vdz2vBh57lS8eg47WY2Ox9AHtUpet_98bH2avkQA</recordid><startdate>196801</startdate><enddate>196801</enddate><creator>Thurø Carstensen, J.</creator><creator>Johnson, J.B.</creator><creator>Spera, D.C.</creator><creator>Frank, M.J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196801</creationdate><title>Equilibrium Phenomena in Solid Dosage Forms</title><author>Thurø Carstensen, J. ; Johnson, J.B. ; Spera, D.C. ; Frank, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-197a868f814c8c5cc42fba42afb06fee2d770c04e292f8c94665a4eff1438fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Chemistry, Pharmaceutical</topic><topic>Dosage Forms</topic><topic>Drug Stability</topic><topic>Drug stability in solid dosage forms</topic><topic>Equilibrium phenomena</topic><topic>Mathematics</topic><topic>Succinates - analysis</topic><topic>Temperature</topic><topic>TLC determination of free tocopherol</topic><topic>UV analysis</topic><topic>Vitamin A - analysis</topic><topic>Vitamin A decay</topic><topic>Vitamin E - analysis</topic><topic>Vitamin E decay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurø Carstensen, J.</creatorcontrib><creatorcontrib>Johnson, J.B.</creatorcontrib><creatorcontrib>Spera, D.C.</creatorcontrib><creatorcontrib>Frank, M.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thurø Carstensen, J.</au><au>Johnson, J.B.</au><au>Spera, D.C.</au><au>Frank, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Equilibrium Phenomena in Solid Dosage Forms</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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| ispartof | Journal of pharmaceutical sciences, 1968-01, Vol.57 (1), p.23-27 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84864693 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Chemistry, Pharmaceutical Dosage Forms Drug Stability Drug stability in solid dosage forms Equilibrium phenomena Mathematics Succinates - analysis Temperature TLC determination of free tocopherol UV analysis Vitamin A - analysis Vitamin A decay Vitamin E - analysis Vitamin E decay |
| title | Equilibrium Phenomena in Solid Dosage Forms |
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