Equilibrium Phenomena in Solid Dosage Forms

Equilibrium Phenomena in Solid Dosage Forms

Certain aspects of the mechanics of drug decay in solid dosage forms are discussed. Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fair...

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Veröffentlicht in:Journal of pharmaceutical sciences 1968-01, Vol.57 (1), p.23-27
Hauptverfasser: Thurø Carstensen, J., Johnson, J.B., Spera, D.C., Frank, M.J.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry, Pharmaceutical
Dosage Forms
Drug Stability
Drug stability in solid dosage forms
Equilibrium phenomena
Mathematics
Succinates - analysis
Temperature
TLC determination of free tocopherol
UV analysis
Vitamin A - analysis
Vitamin A decay
Vitamin E - analysis
Vitamin E decay
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Beschreibung
Zusammenfassung:Certain aspects of the mechanics of drug decay in solid dosage forms are discussed. Apparent equilibration often takes place in solid dosage forms. In order to obtain data that are amenable to detection of equilibria and can be subjected to mathematical analysis, it is necessary, in the case of fairly stable drugs, to assay for degradation products. Van't Hoff plots should be used in this case.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600570104