Determination of Free Salicylic Acid in Buffered Aspirin Tablets

Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined a...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1968-04, Vol.57 (4), p.631-633
Hauptverfasser:	Levine, Joseph, Weber, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin - analysis Aspirin tablets Aspirin tablets, buffered—free salicylic acid buffered-free salicylic acid Buffers Chloroform diluent Chromatography Column chromatography-separation Drug Stability Formic acid-preanalysis sample wetting free-analysis Hydrolysis rate-aspirin Salicylates - analysis Salicylic acid Salicylic acid, free—analysis Silicon Dioxide Solubility Spectrophotometry Tablets - analysis Ultraviolet Rays UV spectrophotometry-identity
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