Determination of Free Salicylic Acid in Buffered Aspirin Tablets

Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined a...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1968-04, Vol.57 (4), p.631-633
Hauptverfasser:	Levine, Joseph, Weber, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin - analysis Aspirin tablets Aspirin tablets, buffered—free salicylic acid buffered-free salicylic acid Buffers Chloroform diluent Chromatography Column chromatography-separation Drug Stability Formic acid-preanalysis sample wetting free-analysis Hydrolysis rate-aspirin Salicylates - analysis Salicylic acid Salicylic acid, free—analysis Silicon Dioxide Solubility Spectrophotometry Tablets - analysis Ultraviolet Rays UV spectrophotometry-identity
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Beschreibung
Zusammenfassung:	Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined as previously described.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600570418