Determination of Free Salicylic Acid in Buffered Aspirin Tablets
Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined a...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-04, Vol.57 (4), p.631-633 |
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| container_end_page | 633 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 57 |
| creator | Levine, Joseph Weber, John D. |
| description | Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined as previously described. |
| doi_str_mv | 10.1002/jps.2600570418 |
| format | Article |
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The salicylic acid is isolated and determined as previously described.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600570418</identifier><identifier>PMID: 4297322</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Aspirin - analysis ; Aspirin tablets ; Aspirin tablets, buffered—free salicylic acid ; buffered-free salicylic acid ; Buffers ; Chloroform diluent ; Chromatography ; Column chromatography-separation ; Drug Stability ; Formic acid-preanalysis sample wetting ; free-analysis ; Hydrolysis rate-aspirin ; Salicylates - analysis ; Salicylic acid ; Salicylic acid, free—analysis ; Silicon Dioxide ; Solubility ; Spectrophotometry ; Tablets - analysis ; Ultraviolet Rays ; UV spectrophotometry-identity</subject><ispartof>Journal of pharmaceutical sciences, 1968-04, Vol.57 (4), p.631-633</ispartof><rights>1968 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-3e359e3485adbe8a8d18115c39896ab498330e7b25e7b58b22ef485c1abdad3a3</citedby><cites>FETCH-LOGICAL-c4278-3e359e3485adbe8a8d18115c39896ab498330e7b25e7b58b22ef485c1abdad3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600570418$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600570418$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4297322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levine, Joseph</creatorcontrib><creatorcontrib>Weber, John D.</creatorcontrib><title>Determination of Free Salicylic Acid in Buffered Aspirin Tablets</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined as previously described.</description><subject>Aspirin - analysis</subject><subject>Aspirin tablets</subject><subject>Aspirin tablets, buffered—free salicylic acid</subject><subject>buffered-free salicylic acid</subject><subject>Buffers</subject><subject>Chloroform diluent</subject><subject>Chromatography</subject><subject>Column chromatography-separation</subject><subject>Drug Stability</subject><subject>Formic acid-preanalysis sample wetting</subject><subject>free-analysis</subject><subject>Hydrolysis rate-aspirin</subject><subject>Salicylates - analysis</subject><subject>Salicylic acid</subject><subject>Salicylic acid, free—analysis</subject><subject>Silicon Dioxide</subject><subject>Solubility</subject><subject>Spectrophotometry</subject><subject>Tablets - analysis</subject><subject>Ultraviolet Rays</subject><subject>UV spectrophotometry-identity</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9P2zAYhi3ExArjutuknLil-Hec20pZyyY0JsG0aRfLsb9IZmkS7GTQ_x6jVJ12QDvYlvw97yt9D0LvCZ4TjOn5fR_nVGIsCsyJOkAzIijOJSbFIZolgOZM8PItOo7xHmMssRBH6IjTsmCUztDHSxggbHxrBt-1WVdnqwCQ3ZrG22062cJ6l_k2uxjrGgK4bBF7H9LHnakaGOI79KY2TYTT3XuCvq8-3S2v8uub9efl4jq3nBYqZ8BECYwrYVwFyihHFCHCslKV0lS8VIxhKCoq0iVURSnUCbbEVM44ZtgJOpt6-9A9jBAHvfHRQtOYFroxasWV5JKyBM4n0IYuxgC17oPfmLDVBOsXZTop03-VpcCHXfNYbcDt8Z2jNC-n-aNvYPufNv3l2-0_3fmU9XGAp33WhN9aFqwQ-sfXtV4Rul7yn7-0TLyaeEgq_3gIOloPrQXnA9hBu86_tsYzWSuYYg</recordid><startdate>196804</startdate><enddate>196804</enddate><creator>Levine, Joseph</creator><creator>Weber, John D.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196804</creationdate><title>Determination of Free Salicylic Acid in Buffered Aspirin Tablets</title><author>Levine, Joseph ; Weber, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-3e359e3485adbe8a8d18115c39896ab498330e7b25e7b58b22ef485c1abdad3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Aspirin - analysis</topic><topic>Aspirin tablets</topic><topic>Aspirin tablets, buffered—free salicylic acid</topic><topic>buffered-free salicylic acid</topic><topic>Buffers</topic><topic>Chloroform diluent</topic><topic>Chromatography</topic><topic>Column chromatography-separation</topic><topic>Drug Stability</topic><topic>Formic acid-preanalysis sample wetting</topic><topic>free-analysis</topic><topic>Hydrolysis rate-aspirin</topic><topic>Salicylates - analysis</topic><topic>Salicylic acid</topic><topic>Salicylic acid, free—analysis</topic><topic>Silicon Dioxide</topic><topic>Solubility</topic><topic>Spectrophotometry</topic><topic>Tablets - analysis</topic><topic>Ultraviolet Rays</topic><topic>UV spectrophotometry-identity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Joseph</creatorcontrib><creatorcontrib>Weber, John D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Joseph</au><au>Weber, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Free Salicylic Acid in Buffered Aspirin Tablets</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1968-04</date><risdate>1968</risdate><volume>57</volume><issue>4</issue><spage>631</spage><epage>633</epage><pages>631-633</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Aspirin and free saliyclic acid are quantitatively released from buffered aspirin tablets, with a negligible degree of hydrolysis of aspirin, by briefly wetting the sample with 98—100 percent formic acid, followed by immediate dilution with chloroform. The salicylic acid is isolated and determined as previously described.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4297322</pmid><doi>10.1002/jps.2600570418</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1968-04, Vol.57 (4), p.631-633 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84864623 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aspirin - analysis Aspirin tablets Aspirin tablets, buffered—free salicylic acid buffered-free salicylic acid Buffers Chloroform diluent Chromatography Column chromatography-separation Drug Stability Formic acid-preanalysis sample wetting free-analysis Hydrolysis rate-aspirin Salicylates - analysis Salicylic acid Salicylic acid, free—analysis Silicon Dioxide Solubility Spectrophotometry Tablets - analysis Ultraviolet Rays UV spectrophotometry-identity |
| title | Determination of Free Salicylic Acid in Buffered Aspirin Tablets |
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