Effect of Experimental Portacaval Shunt on Hepatic Drug Metabolizing Enzymes

Summary Diversion of the portal flow from the liver in rats results in a reduction of the activities of hepatic drug metabolizing enzymes. Such animals still respond to phenobarbital with an increase in hepatic enzyme levels and hypertrophy of smooth endoplasmic reticulum in hepatocytes. It is sugge...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1968-02, Vol.127 (2), p.444-447
Hauptverfasser:	Rubin, Emanuel, Hutterer, Ferenc, Ohshiro, Takeshi, Jacobson, Julius H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endoplasmic Reticulum - drug effects Liver - cytology Liver - drug effects Liver - enzymology Male Microscopy, Electron Mixed Function Oxygenases - metabolism Oxidoreductases - metabolism Phenobarbital - pharmacology Portacaval Shunt, Surgical Rats
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Zusammenfassung:	Summary Diversion of the portal flow from the liver in rats results in a reduction of the activities of hepatic drug metabolizing enzymes. Such animals still respond to phenobarbital with an increase in hepatic enzyme levels and hypertrophy of smooth endoplasmic reticulum in hepatocytes. It is suggested that a defect in the detoxifying ability of the liver itself may play an additional role in portasystemic encephalopathy in man.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-127-32711