Citrullinemia
In their exceptionally interesting article, "Citrullinemia with defective urea production,"1 the authors discuss the metabolism of arginine in their citrullinemic patient: When given for a sustained period, arginine increased the production of urea stoichiometrically but equi-molar amounts...
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| Veröffentlicht in: | Pediatrics (Evanston) 1968-03, Vol.41 (3), p.690-690 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | In their exceptionally interesting article, "Citrullinemia with defective urea production,"1 the authors discuss the metabolism of arginine in their citrullinemic patient:
When given for a sustained period, arginine increased the production of urea stoichiometrically but equi-molar amounts of ornithine, citrulline, argininosuccinic acid, and arginine were not recovered from the urine. . . . Nitrogen balances in addition to protein and arginine loading studies suggest alternate pathways for the degradation of arginine.
According to our investigations2, considerable activity of ornithine-ketoacid aminotransferase (EC 2.6.1.13) can be demonstrated in human liver tissue. |
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| ISSN: | 0031-4005 1098-4275 |
| DOI: | 10.1542/peds.41.3.690 |