Selection of Cell Populations in Induction of Tolerance: Affinity of Antibody Formed in Partially Tolerant Rabbits

Induction of partial tolerance to a haptenic determinant, by the neonatal injection of antigen, resulted in a decrease in the affinity of the antibody formed. Thus, tolerance was more readily induced in those cells capable of synthesizing high affinity as opposed to low affinity antibody. The result...

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Veröffentlicht in:	The Journal of immunology (1950) 1968-01, Vol.100 (1), p.138-141
Hauptverfasser:	Theis, Gail A, Siskind, Gregory W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibody Formation Antigen-Antibody Reactions Dinitrophenols Haptens Horses Immune Tolerance Rabbits Serum Albumin Thermodynamics
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Beschreibung
Zusammenfassung:	Induction of partial tolerance to a haptenic determinant, by the neonatal injection of antigen, resulted in a decrease in the affinity of the antibody formed. Thus, tolerance was more readily induced in those cells capable of synthesizing high affinity as opposed to low affinity antibody. The results are interpreted in terms of a thermodynamically driven selection of cell populations participating in immunologic reactions.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.100.1.138