Transformation of cholic acid by the culture mycobacterium N 1210

Transformation of cholic acid by the culture mycobacterium N 1210

The microbiological transformation of cholic acid by the culture Mycobacterium N 1210 has been studied. The following products have been isolated in the form of methyl esters: 7α-hydroxy-3,12-diketo-Δ 4-cholenic (IIIa), 7α-hydroxy-3,12-diketo-Δ 4-bisnorcholenic (IVa), 7α-hydroxy-3,12-diketo-Δ 4,8(9)...

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Veröffentlicht in:Tetrahedron 1968-01, Vol.24 (5), p.2145-2153
Hauptverfasser: Severina, L.O., Torgov, I.V., Skrjabin, G.K., Wulfson, N.S., Zaretskii, V.I., Papernaja, I.B.
Format: Artikel
Sprache:eng
Schlagworte:
Bile Acids and Salts - metabolism
Biotransformation
Chemical Phenomena
Chemistry
Cholanes
Mycobacterium - metabolism
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Zusammenfassung:The microbiological transformation of cholic acid by the culture Mycobacterium N 1210 has been studied. The following products have been isolated in the form of methyl esters: 7α-hydroxy-3,12-diketo-Δ 4-cholenic (IIIa), 7α-hydroxy-3,12-diketo-Δ 4-bisnorcholenic (IVa), 7α-hydroxy-3,12-diketo-Δ 4,8(9)-bisnorcholadienic (Va), 7-hydroxy-3,12-diketo-Δ 4,6-bisnorcholadienic (VIa), 12α-hydroxy-3-keto-Δ 4,6-choladienic (VIIa), 12α-hydroxy-3-keto-Δ 4,6-bisnorcholadienic (VIIIa) and 3,12-diketo-Δ 4,6-bisnorcholadienic (IXa) acids.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(68)88116-5