Viral Neoplastic Transformation of Hamster Prostate Tissue in vitro

Cultures of hamster prostatic tissues infected with simian virus 40 undergo transformation in vitro, and the transformed cells produce malignant tumors when injected into homologous hosts. Tartrate-inhibited acid phosphastase is found in the cultures of transformed cells and in the tumors they produ...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1968-01, Vol.159 (3811), p.200-201
Hauptverfasser:	Paulson, David F., Rabson, Alan S., Fraley, Elwin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - blood Acid Phosphatase - metabolism Animals Bottles Cell growth Cricetinae Culture Techniques Cultured cells Cytopathogenic Effect, Viral Epithelial cells Histology Infections Kidney cells Male Neoplasms, Experimental - etiology Neoplastic cell transformation Phosphatases Prostatic Neoplasms - etiology Prostatic Neoplasms - pathology Simian virus 40 - pathogenicity Tartrates Tumors
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Beschreibung
Zusammenfassung:	Cultures of hamster prostatic tissues infected with simian virus 40 undergo transformation in vitro, and the transformed cells produce malignant tumors when injected into homologous hosts. Tartrate-inhibited acid phosphastase is found in the cultures of transformed cells and in the tumors they produce. Tartrate-inhibited acid phosphatase activity is elevated in the serum of tumor-bearing animals.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.159.3811.200