Palladium(II)-Catalyzed CH Bond Arylation of Electron-Deficient Arenes at Room Temperature

Mild and tolerant: A novel PdII‐catalyzed CH bond arylation with aryl‐BF3K salts transforms various electron‐deficient arenes under mild reaction conditions. Benzaldehydes are functionalized in the ortho position using a temporary imine directing group that controls the cyclopalladation. A broad ra...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-02, Vol.50 (5), p.1076-1079
Hauptverfasser:	Tredwell, Matthew J., Gulias, Moises, Gaunt Bremeyer, Nadine, Johansson, Carin C. C., Collins, Beatrice S. L., Gaunt, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	arylation Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Catalysis CH functionalization Imines - chemical synthesis Imines - chemistry Palladium - chemistry palladium catalysis site-selective reactions synthetic methods Temperature
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Beschreibung
Zusammenfassung:	Mild and tolerant: A novel PdII‐catalyzed CH bond arylation with aryl‐BF3K salts transforms various electron‐deficient arenes under mild reaction conditions. Benzaldehydes are functionalized in the ortho position using a temporary imine directing group that controls the cyclopalladation. A broad range of benzaldimines are compatible with this process (see scheme).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201005990