Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Rhodium-Catalyzed [2+2+2] Cycloaddition

Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Rhodium-Catalyzed [2+2+2] Cycloaddition

It's all in the application! An enantioselective synthesis of axially chiral 1‐arylisoquinolines has been achieved, which involves a rhodium‐catalyzed [2+2+2] cycloaddition of diphenylphosphinoyl‐substituted 1‐arylisoquinolines (see scheme). The new diphenylphosphinoyl‐substituted axially chira...

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Veröffentlicht in:Chemistry : a European journal 2011-02, Vol.17 (5), p.1428-1432
Hauptverfasser: Sakiyama, Norifumi, Hojo, Daiki, Noguchi, Keiichi, Tanaka, Ken
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
axial chirality
Chemistry
cycloaddition
isoquinolines
N ligand
P,N ligand
Rhodium
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Zusammenfassung:It's all in the application! An enantioselective synthesis of axially chiral 1‐arylisoquinolines has been achieved, which involves a rhodium‐catalyzed [2+2+2] cycloaddition of diphenylphosphinoyl‐substituted 1‐arylisoquinolines (see scheme). The new diphenylphosphinoyl‐substituted axially chiral 1‐arylisoquinolines were successfully derivatized to the corresponding axially chiral P,N ligand and Lewis base catalyst.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201003134