Titration Patterns of a Murine Sarcoma-Leukemia Virus Complex: Evidence for Existence of Competent Sarcoma Virions

Titration Patterns of a Murine Sarcoma-Leukemia Virus Complex: Evidence for Existence of Competent Sarcoma Virions

Stocks of murine sarcoma virus show titration patterns ranging from one- to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that do...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1968-01, Vol.159 (3812), p.325-329
Hauptverfasser: O'Connor, Timothy E., Fischinger, Peter J.
Format: Artikel
Sprache:eng
Schlagworte:
3T3 cells
Animals
Cell lines
Culture Techniques
Defective Viruses
Embryonic cells
Genetics, Microbial
Helper Viruses
Kinetics
Leukemia
Leukemia Virus, Murine - pathogenicity
Mice
Models, Biological
Moloney murine leukemia virus - pathogenicity
Murine leukemia virus
Murine sarcoma viruses
Rauscher Virus
RNA, Viral
Sarcoma
Sarcoma, Experimental
Titration
Viral Proteins
Virions
Viruses
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Zusammenfassung:Stocks of murine sarcoma virus show titration patterns ranging from one- to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that does not need co-infecting murine leukemia virus to be manifested as a focus-forming unit. The behavior of such nondefective particles is compatible with a postulated leukemia-sarcoma virus hybrid.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.159.3812.325