Multiple congenital skin webbing with Cutis laxa

Reports are reviewed of sporadic and familial cases of congenital skin webbing, apart from certain well recognised syndromes. A family is described with at least two cases of cutis laxa apparently due to a deficient attachment of skin and subcutaneous tissues to deep fascia. The index case had, in addition, multiple congenital skin webs with talipes equinovarus, undescended testes and bilateral inguinal herniae. Investigations revealed an anomaly of chromosome 16 inherited through at least two generations. Its occurrence in the family makes it clear that it is unlikely to be directly related either to the cutis laxa or to the other phenotypic abnormalities in the index case.