Prognostic value of serial B-type natriuretic peptide measurement in asymptomatic organic mitral regurgitation

Aims Optimal timing of surgery is crucial in mitral regurgitation (MR) to avoid excess mortality and morbidity. The role of brain‐type natriuretic peptide (BNP) in this setting remains controversial. We evaluated the value of serial BNP measurements for early prediction of deterioration in asymptoma...

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Veröffentlicht in:	European journal of heart failure 2011-02, Vol.13 (2), p.163-169
Hauptverfasser:	Klaar, Ursula, Gabriel, Harald, Bergler-Klein, Jutta, Pernicka, Elisabeth, Heger, Maria, Mascherbauer, Julia, Rosenhek, Raphael, Binder, Thomas, Maurer, Gerald, Baumgartner, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers - blood Cohort Studies Disease Progression Echocardiography Electrocardiography Female Humans Male Middle Aged Mitral regurgitation Mitral Valve Insufficiency - blood Mitral Valve Insufficiency - diagnosis Multivariate Analysis Natriuretic Peptide, Brain - blood Natriuretic peptides Predictive Value of Tests Predictors of outcome Prognosis Proportional Hazards Models Risk Assessment Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Ventricular Function, Left - physiology
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Zusammenfassung:	Aims Optimal timing of surgery is crucial in mitral regurgitation (MR) to avoid excess mortality and morbidity. The role of brain‐type natriuretic peptide (BNP) in this setting remains controversial. We evaluated the value of serial BNP measurements for early prediction of deterioration in asymptomatic MR. Methods and results Eighty‐seven consecutive asymptomatic patients with severe organic MR, normal left ventricular (LV) function (ejection fraction ≥60%, end‐systolic diameter index
ISSN:	1388-9842 1879-0844
DOI:	10.1093/eurjhf/hfq189