Zeb1 and twist are more commonly expressed in metastatic than primary lung tumours and show inverse associations with claudins

Zeb1 and twist are more commonly expressed in metastatic than primary lung tumours and show inverse associations with claudins

BackgroundZeb1 and twist regulate expression of genes which take part in epitheliomesenchymal transition (EMT). Claudins are tight junctional proteins regulating polarity and paracellular permeability of epithelial cells.Aims and methodsTo study Zeb1 and twist in 289 primary and 54 metastatic lung t...

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Veröffentlicht in:Journal of clinical pathology 2011-02, Vol.64 (2), p.136-140
Hauptverfasser: Merikallio, Heta, Kaarteenaho, Riitta, Pääkkö, Paavo, Lehtonen, Siri, Hirvikoski, Pasi, Mäkitaro, Riitta, Harju, Terttu, Soini, Ylermi
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Biological and medical sciences
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - pathology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Differentiation
Claudins - metabolism
Colorectal cancer
Histology
Homeodomain Proteins - metabolism
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Laboratories
Liver cancer
lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - secondary
Medical prognosis
Medical sciences
Metastasis
Neoplasm Proteins - metabolism
Nuclear Proteins - metabolism
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Permeability
pulmonary pathology
Transcription factors
Transcription Factors - metabolism
Tumors
Twist-Related Protein 1 - metabolism
Zinc Finger E-box-Binding Homeobox 1
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Zusammenfassung:BackgroundZeb1 and twist regulate expression of genes which take part in epitheliomesenchymal transition (EMT). Claudins are tight junctional proteins regulating polarity and paracellular permeability of epithelial cells.Aims and methodsTo study Zeb1 and twist in 289 primary and 54 metastatic lung tumours and their relation to expression of claudins 1–5 and 7 by immunohistochemistry.ResultsMetastatic tumours showed a significantly lower expression of zeb1 and twist (33.0% and 38.0% vs 5.0% and 14.5%, p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2010.086678