RNA Dependent DNA Polymerase of Human Acute Leukaemic Cells

RNA Dependent DNA Polymerase of Human Acute Leukaemic Cells

An RNA dependent DNA polymerase analogous to that of RNA tumour viruses has been found in lymphoblasts of leukaemic patients but not of normal donors. The enzyme can use an RNA template from mammalian cells to synthesize DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1970-12, Vol.228 (5275), p.927-929
Hauptverfasser: GALLO, ROBERT C, YANG, STRINGNER S, TING, ROBERT C
Format: Artikel
Sprache:eng
Schlagworte:
Cell Transformation, Neoplastic
DNA Nucleotidyltransferases - analysis
DNA Nucleotidyltransferases - antagonists & inhibitors
Humanities and Social Sciences
Humans
Leukemia, Lymphoid - enzymology
Lymphocytes - enzymology
Methods
multidisciplinary
RNA
Science
Science (multidisciplinary)
Templates, Genetic
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Beschreibung
Zusammenfassung:An RNA dependent DNA polymerase analogous to that of RNA tumour viruses has been found in lymphoblasts of leukaemic patients but not of normal donors. The enzyme can use an RNA template from mammalian cells to synthesize DNA.
ISSN:0028-0836
1476-4687
DOI:10.1038/228927a0