Heterogeneity of Mitochondrial Membrane Potential: A Novel Tool to Isolate and Identify Cancer Stem Cells from a Tumor Mass?

It is believed that cancer stem cells (CSCs) are precursors for the formation, development, and recurrence of malignant tumors. However, it has proven difficult to isolate and enrich these rare, undifferentiated cells from heterogeneous tumor masses. With some existing reports and preliminary result...

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Veröffentlicht in:	Stem cell reviews 2011-03, Vol.7 (1), p.153-160
Hauptverfasser:	Ye, Xiao-Qun, Wang, Guang-Hui, Huang, Gui-Jun, Bian, Xiu-Wu, Qian, Gui-Sheng, Yu, Shi-Cang
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD - metabolism Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cancer Cell Biology Cell Line, Tumor Cell Separation - methods Glycoproteins - metabolism Humans Life Sciences Membrane Potential, Mitochondrial Models, Biological Neoplasms - pathology Neoplastic Stem Cells - pathology Peptides - metabolism Regenerative Medicine/Tissue Engineering Side-Population Cells - pathology Spheroids, Cellular - pathology Stem Cells
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Zusammenfassung:	It is believed that cancer stem cells (CSCs) are precursors for the formation, development, and recurrence of malignant tumors. However, it has proven difficult to isolate and enrich these rare, undifferentiated cells from heterogeneous tumor masses. With some existing reports and preliminary results in mind, we hypothesized that the mitochondrial membrane potential within a tumor mass was heterogeneous and could be used as a tool to isolate and enrich CSCs.
ISSN:	1550-8943 2629-3269 1558-6804 2629-3277
DOI:	10.1007/s12015-010-9122-9