Steroid formation by the avian ovary in vitro ( Gallus domesticus)

Ovarian slices of the Gallus domesticus in the presence of gonadotrophin incorporate acetate-1- 14C into progesterone, androstenedione, testosterone, and estradiol-17β. Distinct profiles of radioactive steroids are seen in the tissues of the molting, laying, and broody hens. There is an intense Δ 5,...

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Veröffentlicht in:	General and comparative endocrinology 1970-08, Vol.15 (1), p.6-11
Hauptverfasser:	Boucek, Robert J., Savard, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Ketosteroids - biosynthesis Acetates - metabolism Androstanes - biosynthesis Animals Birds - metabolism Carbon Isotopes Chickens - metabolism Estradiol - biosynthesis Female Histocytochemistry Hydroxysteroid Dehydrogenases - metabolism In Vitro Techniques Ovarian Follicle - enzymology Ovary - metabolism Progesterone - biosynthesis Radioisotope Dilution Technique Steroids - biosynthesis Testosterone - biosynthesis
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Zusammenfassung:	Ovarian slices of the Gallus domesticus in the presence of gonadotrophin incorporate acetate-1- 14C into progesterone, androstenedione, testosterone, and estradiol-17β. Distinct profiles of radioactive steroids are seen in the tissues of the molting, laying, and broody hens. There is an intense Δ 5,3 β-hydroxysteroid dehydrogenase reaction and 17β-hydroxysteroid dehydrogenase reaction in the granulosa cells of the laying hen; these reactions are not present in the molting hen. An intense 17β-hydroxysteroid dehydrogenase reaction, with testosterone as the substrate, occurs in the theca and stroma cells of the molting hen with only a weak reaction in the laying hen.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/0016-6480(70)90090-0