In vitro Conversion of 7α -Hydroxycholesterol to Some Natural C24-Bile Acids with Special Reference to Chenodeoxycholic Acid Biogenesis

7α -Hydroxycholesterol-−14C was incubated with fortified rat mitochondria and the following C24-bile acids were identified: 3β, 7α-dihydroxychol-5-enoic acid, chenodeoxy-cholic acid and α-muricholic acid. From these and previous data the following new pathway of chenodeoxycholic acid biogenesis is p...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1970-09, Vol.68 (3), p.341-346
Hauptverfasser:	AYAKI, Yoshikazu, YAMASAKI, Kazumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - biosynthesis Carbon Isotopes Cholesterol - metabolism Chromatography In Vitro Techniques Mitochondria, Liver - metabolism Rats Sterols - metabolism
Online-Zugang:	Volltext
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Zusammenfassung:	7α -Hydroxycholesterol-−14C was incubated with fortified rat mitochondria and the following C24-bile acids were identified: 3β, 7α-dihydroxychol-5-enoic acid, chenodeoxy-cholic acid and α-muricholic acid. From these and previous data the following new pathway of chenodeoxycholic acid biogenesis is proposed: cholesterol→7α-hydroxycholesterol→3β, 7α -dihydroxychol-5-enoic acid→chenodeoxycholic acid.
ISSN:	0021-924X 1756-2651
DOI:	10.1093/oxfordjournals.jbchem.a129364