Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat
Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproducti...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1970-09, Vol.59 (9), p.1267-1270 |
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| container_end_page | 1270 |
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| container_issue | 9 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 59 |
| creator | Holck, Harald G.O. Lish, Paul M. Sjogren, David W. Westerfeld, W.W. Malone, Marvin H. |
| description | Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent. |
| doi_str_mv | 10.1002/jps.2600590912 |
| format | Article |
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Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600590912</identifier><identifier>PMID: 5469789</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Age Factors ; Animals ; Ascorbic Acid - pharmacology ; Ascorbic acid effect-disulfiram activity ; Blood Cell Count ; Body Weight - drug effects ; body weight-disulfiram effects ; Diet ; Disulfiram - pharmacology ; Disulfiram-chronic feeding studies ; Disulfiram—chronic feeding studies, rats Blood cells, number—disulfiram effect ; Female ; Growth - drug effects ; Liver - metabolism ; longevity ; Longevity - drug effects ; Male ; Molybdenum - metabolism ; number-disulfiram effect ; Oxygen Consumption - drug effects ; Oxygen consumption-disulfiram effect ; Rats ; rats Blood cells ; Reproduction ; Reproduction - drug effects ; Reproduction, longevity, body weight—disulfiram effects ; Sex Factors ; Xanthine Oxidase - metabolism</subject><ispartof>Journal of pharmaceutical sciences, 1970-09, Vol.59 (9), p.1267-1270</ispartof><rights>1970 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1970 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3822-57d765f37b28e43172d43ce5f82853179c7c0193e22eb54405bbbf9858b7ce883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600590912$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600590912$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5469789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holck, Harald G.O.</creatorcontrib><creatorcontrib>Lish, Paul M.</creatorcontrib><creatorcontrib>Sjogren, David W.</creatorcontrib><creatorcontrib>Westerfeld, W.W.</creatorcontrib><creatorcontrib>Malone, Marvin H.</creatorcontrib><title>Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Ascorbic acid effect-disulfiram activity</subject><subject>Blood Cell Count</subject><subject>Body Weight - drug effects</subject><subject>body weight-disulfiram effects</subject><subject>Diet</subject><subject>Disulfiram - pharmacology</subject><subject>Disulfiram-chronic feeding studies</subject><subject>Disulfiram—chronic feeding studies, rats Blood cells, number—disulfiram effect</subject><subject>Female</subject><subject>Growth - drug effects</subject><subject>Liver - metabolism</subject><subject>longevity</subject><subject>Longevity - drug effects</subject><subject>Male</subject><subject>Molybdenum - metabolism</subject><subject>number-disulfiram effect</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen consumption-disulfiram effect</subject><subject>Rats</subject><subject>rats Blood cells</subject><subject>Reproduction</subject><subject>Reproduction - drug effects</subject><subject>Reproduction, longevity, body weight—disulfiram effects</subject><subject>Sex Factors</subject><subject>Xanthine Oxidase - metabolism</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFP2zAYhq0JxErZlRuST5xIcZw4to-IQQFVbKJFk3axEufzMEvjzk7a9d_PVSrQDtNOlvU976vPjxE6TckkJYRevq7ChBaEMElkSj-gUcooSQqS8gM0igBNMpbLj-g4hFdCSEEYO0JHLC8kF3KEHm-MAd0F7Az-bEPfGOvLJXYtnnq36V4u8My1P2Btu-0FLtsaP8HKu7rXnY1MDHUvgK-ayrYOP5XdCTo0ZRPg0_4co-fbm8X1XTL7Mr2_vpolOhNxJcZrXjCT8YoKyLOU0zrPNDAjqGDxKjXXJJUZUAoVy3PCqqoyUjBRcQ1CZGN0PvTGZX71EDq1tEFD05QtuD4okXMSRezAyQBq70LwYNTK22XptyolaidQRYHqXWAMnO2b-2oJ9Ru-NxbncphvbAPb_7Sph6_zv7qTIWtDB7_fsqX_qQqecaa-PU6VWCwe5mJ-p75HXgw8RJVrC14FbaHVUFsfP03Vzv7rGX8AQvSc8w</recordid><startdate>197009</startdate><enddate>197009</enddate><creator>Holck, Harald G.O.</creator><creator>Lish, Paul M.</creator><creator>Sjogren, David W.</creator><creator>Westerfeld, W.W.</creator><creator>Malone, Marvin H.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197009</creationdate><title>Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat</title><author>Holck, Harald G.O. ; Lish, Paul M. ; Sjogren, David W. ; Westerfeld, W.W. ; Malone, Marvin H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3822-57d765f37b28e43172d43ce5f82853179c7c0193e22eb54405bbbf9858b7ce883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Ascorbic acid effect-disulfiram activity</topic><topic>Blood Cell Count</topic><topic>Body Weight - drug effects</topic><topic>body weight-disulfiram effects</topic><topic>Diet</topic><topic>Disulfiram - pharmacology</topic><topic>Disulfiram-chronic feeding studies</topic><topic>Disulfiram—chronic feeding studies, rats Blood cells, number—disulfiram effect</topic><topic>Female</topic><topic>Growth - drug effects</topic><topic>Liver - metabolism</topic><topic>longevity</topic><topic>Longevity - drug effects</topic><topic>Male</topic><topic>Molybdenum - metabolism</topic><topic>number-disulfiram effect</topic><topic>Oxygen Consumption - drug effects</topic><topic>Oxygen consumption-disulfiram effect</topic><topic>Rats</topic><topic>rats Blood cells</topic><topic>Reproduction</topic><topic>Reproduction - drug effects</topic><topic>Reproduction, longevity, body weight—disulfiram effects</topic><topic>Sex Factors</topic><topic>Xanthine Oxidase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holck, Harald G.O.</creatorcontrib><creatorcontrib>Lish, Paul M.</creatorcontrib><creatorcontrib>Sjogren, David W.</creatorcontrib><creatorcontrib>Westerfeld, W.W.</creatorcontrib><creatorcontrib>Malone, Marvin H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holck, Harald G.O.</au><au>Lish, Paul M.</au><au>Sjogren, David W.</au><au>Westerfeld, W.W.</au><au>Malone, Marvin H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1970-09</date><risdate>1970</risdate><volume>59</volume><issue>9</issue><spage>1267</spage><epage>1270</epage><pages>1267-1270</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5469789</pmid><doi>10.1002/jps.2600590912</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1970-09, Vol.59 (9), p.1267-1270 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Age Factors Animals Ascorbic Acid - pharmacology Ascorbic acid effect-disulfiram activity Blood Cell Count Body Weight - drug effects body weight-disulfiram effects Diet Disulfiram - pharmacology Disulfiram-chronic feeding studies Disulfiram—chronic feeding studies, rats Blood cells, number—disulfiram effect Female Growth - drug effects Liver - metabolism longevity Longevity - drug effects Male Molybdenum - metabolism number-disulfiram effect Oxygen Consumption - drug effects Oxygen consumption-disulfiram effect Rats rats Blood cells Reproduction Reproduction - drug effects Reproduction, longevity, body weight—disulfiram effects Sex Factors Xanthine Oxidase - metabolism |
| title | Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat |
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