Effects of Disulfiram on Growth, Longevity, and Reproduction of the Albino Rat

Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent.